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Gold于1965年在结肠癌组织和2～6个月胎儿肠内发现“糖蛋白”(命名癌胚抗原CEA)后,已广泛应用于消化系癌等临床研究,证明CEA被认为是与癌症有关的物质之一,且其浓度大小和癌的进展有极为密切的关系,但对于甲状腺疾患时CEA的研究资料却较少。作者曾对已确诊之甲状腺癌53例(其中髓样癌15例、乳头状腺癌19例,乳头状滤泡腺癌8例、滤泡腺癌7例、未分化型癌4例)分别进行了CEA值和降钙素测定。作者通过研究甲状腺癌各组织型血清的CEA值,发现甲状腺髓样癌的CEA浓度呈特异性高值。
Gold discovered glycoprotein (named carcinoembryonic antigen CEA) in colon cancer tissues and fetal intestines of 2-6 months in 1965. It has been widely used in clinical studies of digestive system cancer, which proves that CEA is considered to be related to cancer. One of the substances, and its concentration is closely related to the progression of the cancer, but there are few studies on CEA in thyroid disorders. The authors have conducted thyroid cancer diagnosis in 53 cases (including 15 cases of medullary carcinoma, 19 cases of papillary adenocarcinoma, 8 cases of papillary follicular adenocarcinoma, 7 cases of follicular adenocarcinoma, and 4 cases of undifferentiated carcinoma). CEA values and calcitonin determinations. By studying the CEA values of various histological types of thyroid cancer, the authors found that the CEA concentration of medullary thyroid carcinoma has a specific high value.