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小鼠腹水型肝癌(Hca)在昆明种小鼠腹腔内接种含10~6个活瘤细胞的0.1毫升的腹水稀释液,可获100%的成活率,无自行消退。腹水瘤细胞的增长可分为三个时期,即增长期(第1—3天)、高峰期(第4—8天)和递减期(第9天以后)。瘤细胞形态呈圆形,分大、中、小三类,核分裂在接种后前8天较为活跃。宿主寿命为11—28天,平均寿命22.3天,中间存活时间20.5天。在腹水瘤生长过程中见大量小淋巴细胞,吞噬细胞和多形核白细胞,以及淋巴细胞与巨噬细胞包围瘤细胞的现象,这是机体的免疫反应。本瘤株对抗癌药物环磷酰胺的作用较为敏感,其平均腹水量的抑制率为84.4%;延长宿主寿命的中间存活时间为133.3%。瘤细胞形态发生明显变化,出现“晖圆细胞”,“多核瘤巨细胞”及核分裂像大大减少等现象。
Mouse ascites type liver cancer (Hca) inoculated intraperitoneally in Kunming mice with 0.1 to 6 ml of ascites fluid containing 10 to 6 viable tumor cells, and 100% survival rate was achieved without self-report. The growth of ascites tumor cells can be divided into three phases, namely the growth phase (days 1 to 3), the peak phase (days 4 to 8) and the decline phase (after day 9). Tumor cells have a round shape and are divided into large, medium, and small categories. The mitosis is active in the first 8 days after inoculation. The host life is 11-28 days, the average life span is 22.3 days, and the intermediate survival time is 20.5 days. In the process of ascites tumor growth, a large number of small lymphocytes, phagocytes and polymorphonuclear leukocytes, lymphocytes and macrophages surrounding the tumor cells are seen, which is the body’s immune response. This tumor strain is more sensitive to the effect of the anticancer drug cyclophosphamide, with an average inhibition rate of 84.4% for the ascitic fluid and an intermediate survival time of 133.3% for prolonging the host life. The morphological changes of the tumor cells changed significantly, with the appearance of “Hui-round cells,” “multiple-tumor giant cells,” and a dramatic reduction in mitotic figures.