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４５只豚鼠随机分为３组，造成膜迷路积水的模型，对照组右耳作空白对照，两用药组的豚鼠分别于造模后第１天口服大剂量氟桂利嗪（１０ｍｇ／ｋｇ，１／日）及倍他司汀（１０ｍｇ／ｍｇ，２／日）３０天。发现在造模３０天后，实验对照组听性脑干反应（ＡＢＲ）阈值增高，向术侧摆动试验眼震（ＳＰＶＮ）频数下降，蜗内电位（ＥＰ）下降，内淋巴Ｃａ２＋浓度增高，ＥＴ和Ｃａ２＋呈负相关。氟桂利嗪和倍他司汀均能显著抑制前庭性眼震和ＥＰ的下降，抑制内淋巴Ｃａ２＋浓度的增高，对ＡＢＲ反射阈的影响较小。表明氟桂利嗪和倍他司汀在内淋巴积水时对位听功能有保护作用。发现两者均能拮抗迷路积水引起的钙超载，而且疗效无明显差别。推测这两种药物对血管纹微循环的改善以及对内耳毛细胞的保护作用是其治疗作用的基础。
Forty-five guinea pigs were randomly divided into three groups, resulting in a model of labyrinthine membrane loss. The control group received a blank control. The guinea pigs in the two groups were orally administered with flunarizine (10 mg / kg, 1 / day) and betahistine (10mg / mg, 2 / day) for 30 days. After 30 days of modeling, the threshold of auditory brainstem response (ABR) in experimental control group was increased, the frequency of nystagmus (SPVN) decreased, the intima-medial potential (EP) decreased, the concentration of endogenous Ca2 + Ca2 + was negatively correlated. Both flunarizine and betahistine could significantly inhibit the decrease of nystagmus and EP in the vestibular cavity and inhibit the increase of endolymph Ca2 + concentration, which had little effect on the ABR reflex threshold. Show that flunarizine and betahistine in the lymphatic hydrops on the hearing function of a protective effect. Both were found to be able to antagonize the calcium overload caused by lost water, and no significant difference in efficacy. It is speculated that the improvement of these two drugs on vascular microcirculation and the protective effect on inner ear hair cells are the basis of its therapeutic effect.