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自1952年Bessman首先采用重金属络合剂——乙二胺四乙酸二钠钙(CaNa_2EDTA)于临床治疗铅中毒以来,迄今各国学者都一致认为 CaNa_2EDTA是治疗铅中毒最有效、驱铅作用最强的药物。此后,各国学者报告新的治疗铅中毒的药物不多,其中有效的有青霉胺等,但疗效均不如CaNa_2EDTA。1954年上海中国科学院药物研究所合成了解毒新药二巯基丁二酸钠,并证实该药对血吸虫病治疗时发生的锑中
Since 1952, Bessman first used heavy metal complexing agent - disodium edetate (CaNa_2EDTA) in the clinical treatment of lead poisoning, scholars all over the world have so far agreed that CaNa_2EDTA is the most effective treatment of lead poisoning, lead stripping the most effective drug. Since then, scholars from various countries reported that there are not many new drugs for treating lead poisoning, among which penicillamine and the like are effective, but the efficacy is not as good as CaNa_2EDTA. 1954 Shanghai Institute of Materia Medica, Chinese Academy of Sciences synthesized detoxification drug dimercaptosuccinate, and confirmed that the drug treatment of schistosomiasis occurred in the antimony