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目前,肿瘤坏死因子-α(TNF-α)的信号传导机制尚不清楚。以往研究表明,神经磷脂酶反应产物神经鞘氨醇可能具有生物效应剂的性质,细胞可透性的鞘氨醇类似物可刺激人类白血病细胞(IIL-60)的单细胞分化和A431人类皮癌细胞中内皮生长因子受体(EGFR)669位苏氨酸的磷酸化。在HL-60细
At present, the signaling mechanism of tumor necrosis factor-α (TNF-α) remains unclear. Previous studies have shown that the sphingosine product of the phospholipase reaction product may have the properties of a bioeffective agent and the cell-permeable sphingosine analog stimulates single-cell differentiation of human leukemia cells (IIL-60) and A431 human skin cancer Cell phosphorylation of threonine 669 at the endothelial growth factor receptor (EGFR) in cells. The HL-60 is fine