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到１９世纪末期，医学微生物学的发展表明细菌是许多疾病的病因，并且针对细菌的治疗提高了许多疾病的治愈率和生存率，因此那时有人推测细菌与所有疾病包括癌症有关。这个推测伴随着肿瘤遗传学和感染学的发展一直存在争论。肿瘤的部位存在细菌并不能说明细菌就是肿瘤的直接病
By the late 19th century, the development of medical microbiology has shown that bacteria are the cause of many diseases and that the treatment of bacteria increases the cure rate and survival rate of many diseases, so it was speculated that the bacteria were associated with all diseases including cancer. This speculation has been contented with the development of oncology and infection. The presence of bacteria in the tumor does not mean that the bacteria is a direct disease of the tumor