In recent decades, the potential health hazards of microwave exposure have been attracting increasing attention.Our previous studies have demonstrated that microwave exposure impaired leing and memory in experimental animal models[1,2].The synapse is a particular structure for transmitting electrochemical signals between nerve cells in the central nervous system (CNS).Synaptic plasticity regulates leing and memory via releasing neurotransmitters, inducing expression of receptors at synapses, activating intracellular signaling cascades, and by inducing other changes[3,4].Studies from our group and others have reported that microwave exposure could impair synaptic plasticity in rat hippocampus[1,5].However,the underlying mechanisms by which this occurs are still largely unexplored.