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收集我院1993～1996年经肝活检病理确诊的慢性肝炎44例,治疗时间3～38个月,平均9.8月,均为男性,年龄18～57岁,平均37.6岁。两次肝穿间隔时间为2～34个月,平均16.7个月,全部标本均经 HE 染色,诊断按1995年北京全国病毒性肝炎防治会议标准,全部切片按 Scheuer 标准进行分级、分期。分级、分期降低2级或以上者为明显进步,1级者为进步,0级者为无变化,升高者为加重。44例慢性病毒性肝炎两次肝穿结果比较,明显进步9例,进步18例,无变化10例,加重7例。根据病毒血清化验结果分为高复制、低复制,无复制三组。高复制组为 HBsAg、HBeAg、HBVDNA 均阳性,低复制组 HBsAg、HBeAb、HBcAb 均阳性。无复制组为 HBsAg、HBcAb 为阳性,HBV DNA 阴性。将其肝脏炎症程度和病毒复制状态进行对比分析,结果表明:病毒高复制肝脏病变较重,主要是 G3、G4,而低复制和无复制时肝脏病变较轻,主要以 G1、G2为主。在取得进步的27例中有84.2% 由高复制转为低复制或无复制,其中9例明显进步者全部由高复制转为低复制或无复制。近年来,大量重复的肝活检结果提示慢性肝炎各级(期)之
Collecting 44 cases of chronic hepatitis confirmed by pathology of liver biopsy in our hospital from 1993 to 1996, the treatment time was 3-38 months, averaged 9.8 months, all of whom were male, aged from 18 to 57 years with an average of 37.6 years old. The interval between two liver punctures was 2 to 34 months (mean, 16.7 months). All specimens were stained by HE. According to the standard of Beijing National Conference on Prevention and Treatment of Viral Hepatitis in 1995, all the slices were graded and staged according to the Scheuer standard. Grading, stage 2 or more to reduce significantly for the marked improvement, 1 for the progress, 0 no change, increase those who aggravate. Forty-four cases of chronic viral hepatitis were compared between the two liver puncture results, significantly improved in 9 cases, improved in 18 cases, no change in 10 cases, increased in 7 cases. According to the virus serum test results are divided into high copy, low copy, no copy of the three groups. The high copy group was positive for HBsAg, HBeAg and HBVDNA, and the positive for HBsAg, HBeAb and HBcAb in the low copy group. No replication group was HBsAg, HBcAb positive, HBV DNA negative. The degree of liver inflammation and virus replication status were compared and analyzed. The results showed that: the virus high replication liver lesions heavier, mainly G3, G4, and low replication and no replication of liver lesions lighter, mainly G1, G2-based. Of the 27 patients who progressed, 84.2% changed from high to low or no replication, of which 9 significantly improved all from high to low or no replication. In recent years, a large number of repeated liver biopsy prompted all levels of chronic hepatitis (period)