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目的 :观察降纤酶对发病 6小时以上脑梗塞的疗效。方法 :6 0例病人无禁忌症 ,随机分为治疗组和对照组各 30例 ,两组病人治疗前一般情况、神经功能损伤积分、发病至用药时间有可比性。治疗组给予降纤酶首日 15 Bu,第 2、 3日为10 Bu,连用 3次。对照组每日给血栓通 140 mg,连用 2周。于用药前及用药 2周末进行疗效评定及统计神经功能损伤积分。结果 :治疗组的总有效率及显效率明显高于对照组 (P <0 .0 5 ,P <0 .0 1) ,治疗组用药后积分较用药前明显减少 (P <0 .0 1) ,对照组积分用药后较用药前有所减少 (P >0 .0 5 ) ,治疗后治疗组积分减少值明显大于对照组。结论 :降纤酶治疗发病 6～ 48小时脑梗塞仍有较好疗效。
Objective: To observe the effect of defibrase on cerebral infarction more than 6 hours after onset. Methods: Sixty patients without contraindications were randomly divided into the treatment group and the control group, 30 cases each. The general condition, the neurological damage score and the time from onset to treatment of the two groups were comparable. In the treatment group, defibrase was given 15 Bu on the first day and 10 Bu on the 2nd and 3rd day for 3 times. Control group daily thrombus 140 mg, once every 2 weeks. Before treatment and medication for 2 weeks to assess the efficacy and statistical neurological injury score. Results: The total effective rate and markedly effective rate in the treatment group were significantly higher than those in the control group (P <0.05, P <0.01), and the scores of the treatment group were significantly decreased after treatment (P <0.01) , While in the control group, the points after treatment decreased compared with those before treatment (P> 0.05). After treatment, the treatment group decreased significantly more than the control group. Conclusion: Defibrase treatment of cerebral infarction 6 to 48 hours is still a good effect.