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本文资料表明:(1)提高普查技术的灵敏度,能显著提高原发性肝细胞癌的早期诊断率。坚持定期普查可使Ⅰ期肝癌诊断率从4.7%提高到60%以上,漏检率下降到15%。(2)长期随访了血清 AFP 介于50～300毫微克/毫升的低浓度持续阳性患者,这类人群的临床肝癌发生率高达10.3～29.4%,可能成为研究肝癌癌前阻断的主要对象。(3)SGPT 阳性的 AFP 低浓度持续阳性患者,通过 SGPT—AFP时间动态曲线的分离现象有助于提早鉴别诊断。(4)Ⅰ期肝癌患者的手术治疗和AFP 低浓度持续阳性者的中西医结合治疗可能会提高肝癌的疗效。
The data in this paper shows that: (1) Increasing the sensitivity of census techniques can significantly improve the early diagnosis of primary hepatocellular carcinoma. Adherence to regular census can increase the diagnostic rate of stage I liver cancer from 4.7% to over 60%, and the rate of missed diagnosis drops to 15%. (2) Long-term follow-up of low-concentration positive patients with serum AFP between 50 and 300 ng/ml. The incidence of clinical liver cancer in these populations was as high as 10.3 to 29.4%, which may be the main target for the study of precancerous liver cancer. (3) SGPT-positive patients with persistently low levels of AFP are positive, and the separation of the SGPT-AFP time-dynamic curve can help early differential diagnosis. (4) Surgical treatment of patients with stage I liver cancer and combination of Chinese and Western medicine with persistently low AFP concentration may improve the efficacy of liver cancer.