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为观察速激肽NK1受体拮抗剂SR140333对抗原攻击引起的致敏大鼠气道高反应性的影响,测定了致敏大鼠在抗原攻击前后的基础呼吸频率,对MCh的反应性及支气管肺泡灌洗液中的白细胞数量。实验结果显示,致敏大鼠吸入OA后6h基础呼吸频率增加,并显著增加乙酰甲胆碱(MCh)的反应性、MCh的-logPC30值和支气管肺泡灌洗液中的白细胞数量。ip速激肽NK1受体拮抗剂SR140333(01mg·kg-1)或地塞米松(05mg·kg-1),可明显抑制上述反应,小剂量SR140333(001mg·kg-1)仅有部分抑制作用。结果提示抗原攻击可引起致敏大鼠气道高反应性和气道炎症,速激肽NK1受体拮抗剂可抑制这些反应
To observe the effects of tachykinin NK 1 antagonist SR140333 on airway hyperresponsiveness in sensitized rats induced by antigen challenge, the basic respiratory rate of sensitized rats before and after antigen challenge was determined, Reactivity and bronchoalveolar lavage fluid leukocytes. The experimental results showed that 6h after inhalation of sensitized rats, basal respiration rate increased, and significantly increased the reactivity of MCh, the value of -logPC30 of MCh and the number of leukocytes in bronchoalveolar lavage fluid. SR140333 (01mg · kg-1) or dexamethasone (05mg · kg-1) could significantly inhibit the above reaction. The low dose of SR140333 (0 01mg · kg-1) only partial inhibition. The results suggest that antigen challenge can cause allergic airway hyperresponsiveness and airway inflammation, tachykinin NK 1 receptor antagonist can inhibit these reactions