利用对靶基因的 PCR扩增片段进行酶切的方法对武汉地区汉族人血管紧张素原突变体 (M2 35 T与T174M)与原发性高血压发生的关系进行了分析。发现正常人和原发性高血压患者两组间 M2 35 T基因型频率分别为7%和 14% (P>0 .1) ,T174M基因型频率分别为 31%和 5 1% (P>0 .0 5 )。初步结果表明 ,被检测者中血管紧张素原基因突变率在原发性高血压患者和正常人两组间没有显著性差异 The relationship between the angiotensinogen (M235T and T174M) Han and the occurrence of essential hypertension in Wuhan Han population was analyzed by the restriction enzyme digestion of the target gene. The frequency of M235 T genotypes was found to be 7% and 14% in both groups (P> 0. 1) and 31% and 51% (P> 0), respectively, in patients with essential hypertension and essential hypertension .0 5). The preliminary results showed that there was no significant difference in the rate of mutation of angiotensinogen gene among the patients with essential hypertension and normal subjects