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目的 探讨失血性休克再灌注后早期血清磷脂酶A2 (PLA2 )和一氧化氮 (NO)变化的意义以及牛磺酸对其影响。方法 2 4只家兔随机分为三组 (n =8) :对照组 (Ⅰ )、单纯休克组 (Ⅱ )、牛磺酸治疗组 (Ⅲ )。采用失血性休克再灌注模型 ,测定灌注后 0 5、2和 4小时血清PLA2 及NO和丙二醛 (MDA)值。结果 Ⅱ组血压、NO相对Ⅰ组降低明显 ,而PLA2 、MDA显著升高 ,Ⅲ组无明显变化。结论 再灌注后早期PLA2 激活和内源性NO分泌减少 ,对休克再灌注损伤和最终多脏器功能失常综合征 (MODS)衰竭发展起重要作用。牛磺酸对这种损伤具有明显保护作用
Objective To investigate the significance of serum phospholipase A2 (PLA2) and nitric oxide (NO) changes after hemorrhagic shock and reperfusion in rabbits and the effect of taurine on them. Methods 24 rabbits were randomly divided into three groups (n = 8): control group (Ⅰ), shock alone group (Ⅱ) and taurine treatment group (Ⅲ). Hemorrhagic shock and reperfusion models were used to measure serum levels of PLA2, NO and malondialdehyde (MDA) at 0, 5, 2 and 4 hours after perfusion. Results The blood pressure and NO in group Ⅱ were significantly lower than those in group Ⅰ, while the levels of PLA2 and MDA were significantly increased in group Ⅱ, but not in group Ⅲ. Conclusion The decrease of PLA2 activation and endogenous NO secretion early after reperfusion may play an important role in the development of shock and reperfusion injury and eventually the development of MODS. Taurine has obvious protective effect on this kind of damage