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目的建立大鼠血浆中瑞香素的测定方法,观察瑞香素在大鼠体内的药动学行为。方法将大鼠随机分组,分别ig瑞香素溶液250、312.5、375mg/kg,尾iv瑞香素溶液50、62.5、75mg/kg,HPLC测定不同时间间隔的血药浓度,运用DAS1.0药动学程序计算药动学参数。结果大鼠ig给药后符合单室开放模型;iv后也符合单室开放模型。结论瑞香素在大鼠体内能快速分布并消除,两种给药途径瑞香素的体内药动学过程不同,静注和口服给药各有优势。
Objective To establish a method for the determination of daphnetin in rat plasma and observe the pharmacokinetics of daphnetin in rats. Methods Rats were randomly divided into two groups: ig, daphnetin 250, 312.5, 375 mg / kg, caudal ibuprofen 50, 62.5, 75 mg / kg respectively. HPLC was used to determine plasma concentrations at different time intervals. The program calculates pharmacokinetic parameters. Results After ig administration, rats were single-chamber open model, and iv were also single-chamber open model. Conclusion Daphnetin can be rapidly distributed and eliminated in rats. The dosing regimen of daphnetin has different pharmacokinetics in vivo. Both intravenous and oral administration have advantages.