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目的 :观察Ⅰ型干扰素受体1(type I interferon receptor 1,IFNAR1)在口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)及正常口腔黏膜中的表达,探讨其与患者临床特征及预后的关系。方法 :应用免疫组织化学方法检测IFNAR1在108例OSCC及16例正常黏膜组织中的表达水平,分析IFNAR1的表达水平与OSCC临床病理特征的关系。采用SPSS17.0软件包对数据进行统计学分析。结果:IFNAR1在OSCC的表达水平比正常黏膜组织高。IFNAR1的表达水平与T分期、颈淋巴结转移、TNM分期及病理分化程度显著相关(P<0.05);与患者的性别、年龄、发生部位、吸烟和饮酒无相关性(P>0.05)。IFNAR1表达对OSCC患者生存预后的HR=1.879(95%CI=0.967-3.651,P=0.063)。Log-rank检验显示,IFNAR1表达高低与OSCC患者预后相关(P=0.057)。结论 :IFNAR1在OSCC患者中高表达,其表达上调对OSCC是一个潜在的危险因子,与OSCC患者的预后有相关趋势。
OBJECTIVE: To investigate the expression of type I interferon receptor 1 (IFN-γ1) in oral squamous cell carcinoma (OSCC) and normal oral mucosa relationship. Methods: Immunohistochemistry was used to detect the expression of IFNAR1 in 108 cases of OSCC and 16 cases of normal mucosa. The relationship between IFNAR1 expression and clinicopathological features of OSCC was analyzed. SPSS17.0 software package for statistical analysis of the data. Results: The expression level of IFNAR1 in OSCC was higher than that in normal mucosa. The expression level of IFNAR1 was significantly correlated with T stage, cervical lymph node metastasis, TNM stage and pathological differentiation degree (P <0.05). There was no correlation between the expression of IFNAR1 and sex, age, site of occurrence, smoking and drinking (P> 0.05). The prognosis of OSCC patients with IFNAR1 expression was HR = 1.879 (95% CI = 0.967-3.651, P = 0.063). Log-rank test showed that the level of IFNAR1 expression correlated with the prognosis of OSCC patients (P = 0.057). Conclusion: IFNAR1 is overexpressed in OSCC patients. Upregulation of IFNAR1 is a potential risk factor for OSCC, which is related to the prognosis of patients with OSCC.