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湖南雄黄矿有砷接触史职工肺癌普查痰检结果，６１０名受检职工中痰检正常占１７．２％，鳞状化生３９．０％，轻度不典型增生２６．２％，中度不典型增生１１．８％，重度不典型增生４．６％，肺癌１．２％。经７年的复查和随诊，又发现经病理证实的肺癌２６例。肺癌的发生率从痰检正常组、鳞状化生组到不同程度不典型增生组逐渐上升，至重度不典型增生组的１１．５％，显著高于正常组（Ｐ＜０．０５）和鳞化组（Ｐ＜０．０５）。提示该矿肺癌高发可能是在无机砷的作用下，支气管上皮广泛出现鳞状上皮化生，在此基础上出现不典型增生，有些进一步发展成癌。
The results of the examination of lung cancer among staff with arsenic exposure history in the realgar mine in Hunan Province showed that among the 610 employees, 17.2% were normal, 39.0% were squamous metaplasia, 26.2% were mild dysplasia, and moderate 11.8% of atypical hyperplasia, 4.6% of severe dysplasia, and 1.2% of lung cancer. After 7 years of review and follow-up, 26 cases of pathologically confirmed lung cancer were found. The incidence of lung cancer increased gradually from the normal control group, squamous metaplasia group to different degrees of atypical hyperplasia group, to 11.5% of severe dysplasia group, which was significantly higher than the normal group (P<0.05) and Scaled group (P <0.05). It is suggested that the high incidence of lung cancer in this mine may be due to the action of inorganic arsenic. The bronchial epithelium has a wide range of squamous metaplasia. On this basis, atypical hyperplasia occurs, and some further develop into cancer.