【摘 要】
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Dear Editor,L-Fucose (6-deoxy-L-galactose,fucose) is the basic component of a variety of glycan structures.The fucosylated oligosaccharides participate in a var
【机 构】
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Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijin
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Dear Editor,L-Fucose (6-deoxy-L-galactose,fucose) is the basic component of a variety of glycan structures.The fucosylated oligosaccharides participate in a variety of cellular activities,like the cell-cell recognition,selectin-mediated leukocyteendothelial adhesion and the formation of Lewis blood group antigens (Ma et al.,2006).GDP-fucose is an important fucose donor in the process of fucosylated oligosaccharides formation.Two pathways of GDP-fucose synthesis are present in the cytosol of mammalian cells,including the de novo pathway and the salvage pathway (Becker et al.,2003).In the salvage pathway,cells use fucose from the extracellular or lysosomal sources to synthesize GDP-fucose.
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