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临床上常用的青霉素类药物有青霉素G钠(钾)、氨苄青霉素、氧哌嗪青霉素、苯唑青霉素等。使用该类药物须常规做青霉素G皮肤过敏试验(皮试),然而皮试阴性者在注射不同品种的青霉素类药物时,仍有发生过敏反应。我院肺科报告一例,男性,55岁,每日用青霉素G钠480万u加入5%G·S 500ml中静滴,4天后因病情需要,改用氧哌嗪青霉素0.8克加入5%G·S 500ml中静滴,3—5分钟后,患者感到头皮痒,继而胸闷、心慌,烦燥不安,有便意,强行起床即昏到在地,两眼上翻,呼其不应,即皮下注射肾上腺素0.3mg静注地塞米松10mg,约5分钟后,神志清醒,恢复正常。仍然用青霉素G钠每日给640万静滴,无任何不适反应。第15天,又改用氧哌嗪青霉素8.0g加入5%G·S 500ml中静滴,约滴入10ml,患者又感头皮痒,立即终止滴注, 继而全身搔痒,胸部及四肢见风团样荨麻疹,经皮下注
Penicillin commonly used in clinical penicillin G sodium (potassium), ampicillin, piperacillin penicillin, oxacillin and so on. The use of such drugs should be routine to do penicillin G skin allergy test (skin test), but skin test negative in the injection of different varieties of penicillins, there is still an allergic reaction. A report of our hospital pulmonary disease, male, 55 years old, daily with penicillin G 4.8 million u added 5% G · S 500ml intravenous infusion, 4 days after due to illness, use piperacillin penicillin 0.8 g 5% G S 500ml intravenous infusion, 3-5 minutes later, the patient felt itchy scalp, and then chest tightness, palpitation, irritability, meaning, forcibly get up and then faint to the ground, his eyes up, call it should not, that is, under the skin Injection of epinephrine 0.3mg intravenous dexamethasone 10mg, about 5 minutes, conscious, returned to normal. Still with penicillin G daily to 6.4 million intravenous infusion, without any discomfort reaction. On the 15th day, they switched to intravenous infusion of 5% G · S 500ml with 8.0g of piperacillin penicillin, and dropped about 10ml into the solution. The patient then had an itchy scalp. Immediately stop the instillation and then itching, chest and limbs Urticaria, percutaneous injection