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关于氚水(HTO)对哺乳动物遗传效应的资料很少,这可能是由于缺少检测生殖系统突变的常用方法。最近已对小鼠建立了检测突变非常敏感的方法。而且,获得了加倍剂量为33R,每个位点每仑突变率为2.2×10~(-7)。作者用此法确定了剂量-响应关系,并确定了氚水对人类的遗传危险度。选用PT雌鼠与HT雄鼠交配,产生了F_1(具有隐性毛色基因的杂合子),当雌鼠怀孕到第10天的下午2时,按每克体重1次腹腔注射氚水,注射量为4.4,2.2和0.7MBq。对F_1出生后4周进行躯体
Little is known about the genetic effects of tritiated water (HTO) on mammals, probably due to a lack of common methods for detecting reproductive system mutations. Recently mice have been established to detect mutations is very sensitive to the method. Moreover, a doubling dose of 33R was obtained with a mutation rate of 2.2 × 10 -7 per locus per locus. The authors used this method to determine the dose-response relationship and determine the genetic risk of tritiated water to humans. Selection of female and male mice PT mating, resulting in F_1 (recessive coat color genes heterozygous), when the female pregnant to the first 10 days of the afternoon at 2 o’clock, per gram of body weight 1 intraperitoneal injection of tritiated water, injection volume 4.4, 2.2 and 0.7 MBq. 4 weeks after F_1 was born body