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目的探讨C反应蛋白、降钙素原和CD64在儿科临床的应用价值。方法选取2015年3月至2016年3月符合诊断标准的感染性疾病患儿100例,分为病毒感染组40例和细菌感染组60例,另选取同期住院50例非感染患儿为对照组,均行C反应蛋白、降钙素原和CD64检查。比较三组患儿C反应蛋白、降钙素原和CD64测定结果,分析三种检测方式用于细菌感染和病毒感染检查临床的的灵敏度、特异度及准确性。结果细菌感染组C反应蛋白、降钙素原阳性率和CD64水平指数均高于病毒感染组和非感染组,两两对应比较,差异有统计学意义(P<0.05),病毒感染组CD64水平指数高于非感染组,差异有统计学意义(P<0.05)。降钙素原用于细菌感染和病毒感染检测,特异性优于C反应蛋白原,差异有统计学意义(P<0.05)。结论降钙素原和CD64检测方式优于C反应蛋白测定法,可用于儿科感染性疾病早期诊断。
Objective To investigate the clinical value of C-reactive protein, procalcitonin and CD64 in pediatrics. Methods A total of 100 children with infectious diseases who met the diagnostic criteria from March 2015 to March 2016 were selected and divided into 40 cases of viral infection and 60 cases of bacterial infection. Another 50 non-infected inpatients were selected as control group , C line reactive protein, procalcitonin and CD64 examination. The results of C-reactive protein, procalcitonin and CD64 were compared between the three groups. The sensitivity, specificity and accuracy of the three methods for clinical examination of bacterial and viral infections were analyzed. Results The positive rates of C-reactive protein, procalcitonin and CD64 in bacterial infection group were significantly higher than those in non-infected and infected groups (P <0.05). The levels of CD64 The index was higher than the non-infected group, the difference was statistically significant (P <0.05). Procalcitonin was used to detect bacterial infection and virus infection, specificity was better than C-reactive protein, the difference was statistically significant (P <0.05). Conclusions The detection of procalcitonin and CD64 are superior to the C-reactive protein assay and can be used for the early diagnosis of pediatric infectious diseases.