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目的以乳酸-羟基乙酸共聚物[poly(lactic-co-glycolic acid),PLGA]为材料,制备缓释局麻药利多卡因(Lido-caine,LID)-PLGA长效缓释微球。方法采用乳化溶媒挥发法制备微球;采用紫外分光光度法测定微球载药量、包封率和体外药物释放。结果纳米微球形态光滑圆整,球体大小均匀,微球粒径为(174.5±15.2)nm,微球载药量和包封率分别为12.48%和54.30%,微球体外释放符合Higuchi方程,半衰期t1/2=3.45d。结论LID-PLGA纳米微球具有明显缓释作用。
OBJECTIVE To prepare sustained-release local anesthetic LID-PLGA sustained-release microspheres by using lactic acid-co-glycolic acid (PLGA) as material. Methods The microspheres were prepared by emulsification solvent evaporation method. The drug loading, entrapment efficiency and in vitro drug release of microspheres were determined by UV spectrophotometry. Results The morphology of the microspheres was smooth and spherical with a diameter of (174.5 ± 15.2) nm. The loading and entrapment efficiency of the microspheres were 12.48% and 54.30%, respectively. The in vitro release of the microspheres was in accordance with the Higuchi equation, Half-life t1 / 2 = 3.45d. Conclusion LID-PLGA nanospheres have a significant sustained release effect.