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目的 研究慢性乙型肝炎 (CHB)患者庚型肝炎病毒 (HGV)感染的意义。方法 应用RT -PCR法对 14 6例CHB患者血清进行了HGV -RNA检测 ,并将HGV -RNA阳性与阴性患者进行临床与病理学对比。结果 HGV -RNA阳性 2 3例 ( 15 .75 % )。HGV -RNA阳性与阴性患者肝功能等生化指标水平、肝脏病理损害程度、HBV -DNA阳性率均无显著性差异 (P <0 .0 5 )。 5例HGV -RNA阳性、16例HGV -RNA阴性CHB患者干扰素的近期疗效无显著差异 (P >0 .0 5 )。结论 CHBHGV感染并不加重肝脏损害 ,亦不影响HBV的复制及干扰素的疗效 ;HGV致病性可能较弱
Objective To study the significance of hepatitis G virus (HGV) infection in patients with chronic hepatitis B (CHB). Methods HGV-RNA was detected in serum of 146 CHB patients by RT-PCR, and the clinical and pathological changes of HGV-RNA positive and negative patients were compared. Results HGV-RNA positive in 23 cases (15 .75%). HGV-RNA positive and negative patients such as liver function and other biochemical indicators, the degree of liver damage, HBV-DNA positive rate was no significant difference (P <0.05). Among the 5 cases of HGV-RNA positive, there was no significant difference in the short-term efficacy of interferon among 16 cases of HGV-RNA negative CHB patients (P> 0.05). Conclusions CHBHGV infection does not aggravate liver damage and does not affect the replication of HBV and the efficacy of interferon. The pathogenicity of HGV may be weak