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解偶联蛋白(uncoupling proteins,UCPs)是一类位于线粒体内膜上的阴离子载体蛋白,属于线粒体载体蛋白超家族。到目前为止,已经发现并确认UCPs同系物为5种,即UCP1～UCP5,中枢神经系统中主要含有UCP2,UCP4和UCP5 3种亚型,已经证实其对于脑缺血后的氧化应激、线粒体膜电势及ATP绝对水平的维持具有重要的作用,本文主要将UCPs在脑缺血疾病中相关作用进行综述,希望可以为脑缺血疾病的治疗提供新的研究思路。
Uncoupling proteins (UCPs) are a class of anionic carrier proteins located on the mitochondrial inner membrane, belonging to the mitochondrial carrier protein superfamily. So far, it has been found and confirmed UCPs homologues of five, namely UCP1 ~ UCP5, the central nervous system contains mainly UCP2, UCP4 and UCP5 three subtypes has been confirmed that its oxidative stress after cerebral ischemia, mitochondria Membrane potential and the absolute level of ATP plays an important role. In this paper, we mainly reviewed the related roles of UCPs in cerebral ischemia and hope to provide new research ideas for the treatment of cerebral ischemia.