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应用标准玻璃微电极技术，研究哇巴因诱发豚鼠心室乳头肌的延迟后除极（ＤＡＤ）和触发电活动（ＴＡ）的变化规律及特点；探讨普罗帕酮和维拉帕米对ＤＡＤ和ＴＡ的影响。结果表明：①心室肌细胞在高浓度Ｃａ２＋条件下加哇巴因灌流时可以出现ＤＡＤ及ＴＡ，ＴＡ的诱发率为７７．８％（７／９）。②心室肌细胞诱发的ＤＡＤ幅度（ＤＡＤ－Ａｍｐ）、ＤＡＤ偶联间期（ＤＡＤ－Ｃ）和ＤＡＤ升支上升速率（ＤＡＤ－ｄｖ／ｄｔ）呈明显的频率依赖性，即刺激频率愈快，ＤＡＤ－Ａｍｐ愈高、ＤＡＤ－ｄｖ／ｄｔ愈快，ＤＡＤ－Ｃ则愈短。③上述两种抗心律失常药物均通过降低ＤＡＤ－Ａｍｐ、减慢ＤＡＤ－ｄｖ／ｄｔ和延长ＤＡＤ－Ｃ而发挥其抗触发性心律失常作用；两者对哇巴因诱发的ＤＡＤ和ＴＡ的抑制作用无显著性差异，在普罗帕酮或维拉帕米的作用下，哇巴因对ＴＡ的诱发率分别为３３．３％（３／９）和２２．２％（２／９），与哇巴因的诱发率（高钙条件下，７７．８％）比较Ｐ＜０．０１。
The application of standard glass microelectrode technology to study ouabain induced guinea pig ventricular papillary muscle delayed depolarization (DAD) and triggering electrical activity (TA) changes in the law and characteristics; explore propafenone and verapamil on DAD and TA Impact. The results showed that: (1) DAD and TA appeared in ventricular myocytes during perfusion with ouabain in high concentrations of Ca2 +, and the induction rate of TA was 77.8% (7/9). ② The DAD amplitude (DAD-Amp), DAD-C and DAD-dv / dt induced by ventricular myocytes were significantly frequency-dependent, that is, the faster the stimulation frequency, The higher DAD-Amp, the faster the DAD-dv / dt, the shorter the DAD-C. ③ Both antiarrhythmic drugs exert their anti-arrhythmic effects by decreasing DAD-Amp, decreasing DAD-dv / dt and prolonging DAD-C; both of them inhibit ouabain-induced DAD and TA The effect of ouabain on TA was 33.3% (3/9) and 22.2% (2/9), respectively, with propafenone or verapamil, The induction rate of ouabain (77.8% under high calcium conditions) compared P <0.01.