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格林-巴利综合征(Guillain-Barre Syndrome,GBS)是一种自身免疫性周围神经病。目前,其病因及发病机制仍不十分清楚,普遍认为其发病与微生物感染、接种疫苗、自身免疫状况等因素有关。不同类型的GBS临床表现不尽相同,因首发症状多种多样,缺乏特异性,经常会有误诊的情况发生,需要与一些疾病鉴别。近年来,预防接种后发生的GBS备受关注,该文通过检索国内外发表的文献,对GBS的基本情况及预防接种与GBS的因果关系研究进展进行综述。
Guillain-Barre Syndrome (GBS) is an autoimmune peripheral neuropathy. At present, its etiology and pathogenesis are still not very clear, and its incidence is generally believed that the microbial infection, vaccination, autoimmune conditions and other factors. Different types of GBS clinical manifestations vary, due to a variety of first symptoms, the lack of specificity, often misdiagnosis occurs, the need to identify some diseases. In recent years, there has been much concern about GBS after vaccination. This article reviewed the basic situation of GBS and the research progress of the causal relationship between vaccination and GBS by searching published literatures at home and abroad.