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对硝酸甘油唇颊片与国外样品的溶出度和药理作用的比较,表明两者溶出度、T_(max)、V_(max)及AUC_(0→360min 均无显著差别。建议用手指血流阻抗法测定该制剂的相对生物利用度。
Comparison of the dissolution and pharmacological effects of nitroglycerin lip buccal tablets with foreign samples showed that there was no significant difference in dissolution, T max, V max and AUC 0 0 ~ 360min.It is suggested that the finger blood flow impedance Method to determine the relative bioavailability of the formulation.