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对于神经母细胞瘤患者,精确估计肿瘤浸润骨髓的程度是进行有效治疗的重要依据。一岁以上的患儿,若确诊时已累及骨髓(Ⅳ期),则预后不良。神经母细胞瘤是骨髓呈灶性受累的疾患,检查为数不多的瘤细胞,多点活检要比穿刺更准确。然而,对骨髓组织学,细胞学和免疫学的研究价值和应用尚未充分确立。自1983年来,作者已进行广泛的研究,包括对所有病人两侧髂嵴前后四个部位进行活检及穿刺,对其中多数病人还做4个骨髓印片,二个胫骨及一个胸
For patients with neuroblastoma, an accurate estimate of the degree of tumor infiltration of bone marrow is an important basis for effective treatment. Children older than one year, if diagnosed with bone marrow involvement (stage IV), have a poor prognosis. Neuroblastoma is a disease in which the bone marrow is focally involved, and it is rare to examine a few tumor cells. Multipoint biopsy is more accurate than puncture. However, the research value and application of bone marrow histology, cytology and immunology have not been fully established. Since 1983, the author has conducted extensive research, including biopsy and puncture of all patients on both sides of the anterior and posterior four sites. Most of these patients also performed four bone marrow prints, two zygomatic bones and one chest.