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目的分析~(125)I粒子植入治疗腹膜后淋巴结转移瘤癌痛的临床特点。方法采用中文版SF-MPQ-2量表分别在23例腹膜后淋巴结转移瘤癌痛患者行~(125)I粒子植入治疗前及治疗后1 d、2 d、3 d、7 d、28 d、56 d测量,并对数据进行统计学分析。结果治疗后1 d、2 d中文版SF-MPQ-2量表总分有所下降,但与治疗前比较差异无统计学意义(P>0.05),植入治疗后3 d、7 d、28 d、56 d均持续下降,且各时间点与治疗前相比较差异有统计学意义(P<0.01)。量表持续性疼痛维度与阵发性疼痛维度在治疗后1 d评分呈轻微上升,治疗前后差异无统计学意义(P>0.05),治疗后2 d开始两维度分值逐渐下降,3 d、7 d、28 d、56 d评分与治疗前相比较差异有统计学意义(P<0.01);神经病理性疼痛维度评分在治疗后1 d即逐渐下降,并持续下降,各测评时间点分值与治疗前相比较差异均有统计学意义(P<0.01);对情绪影响维度评分治疗后逐渐下降。结论腹膜后淋巴结转移瘤癌痛患者行~(125)I粒子植入治疗后疼痛特点为治疗后持续性疼痛维度和阵发性疼痛维度分值轻度上升,治疗后2 d开始下降,对情绪影响维度分值与神经病理性疼痛维度分值从治疗后1 d起逐渐下降。
Objective To analyze the clinical features of ~ (125) I seed implantation in the treatment of retroperitoneal lymph node metastases cancer pain. Methods The Chinese version of SF-MPQ-2 was used in 23 patients with cancer of the retroperitoneal lymph node metastasis before 125 I seeds implantation and 1 d, 2 d, 3 d, 7 d, 28 d, 56 d measurements, and the data for statistical analysis. Results The total score of SF-MPQ-2 in Chinese version decreased on the 1st and 2nd day after treatment, but there was no significant difference between before and after treatment (P> 0.05) d, 56 d all continued to decline, and each time point compared with before treatment was statistically significant (P <0.01). The dimensions of persistent pain and the dimension of paroxysmal pain increased slightly on the first day after treatment, but there was no significant difference between before and after treatment (P> 0.05) The score of 7d, 28d and 56d was significantly different from that before treatment (P <0.01). The dimension of neuropathic pain decreased gradually on the 1st day after treatment and continued to decline. The score of each time point Before treatment, the differences were statistically significant (P <0.01); the dimension of emotional impact decreased gradually after treatment. Conclusion The pain characteristics of patients with retroperitoneal lymph node metastases and tumor pain after ~ (125) I seed implantation are slight increase of persistent pain dimension and paroxysmal pain dimension after treatment, and decrease gradually on the 2nd day after treatment, The scores of impact dimension and neuropathic pain decreased gradually from the first day after treatment.