论文部分内容阅读
本文对上消化道癌肿患者及部分癌高发家族成员进行了外周血淋巴细胞姐妹染色单体互换的分析,发现癌肿病人及有癌家族史的健康人和炎症患者的SCE 值都高于对照组,差异平均有高度显著性(P<0.01),并且,炎症组的SCE 值又显著地高于健康人(P<0.01)。结果提示上消化道癌肿的发病机制中可能有遗传易感性的参与;其次,SCE 检测对癌家族成员的随访可能有一定的价值。
This article analyzed the peripheral blood lymphocyte sister chromatid exchange for patients with upper gastrointestinal cancer and some high cancer family members. It was found that the SCE values of cancer patients and family history of cancer and inflammatory patients were higher than those of cancer patients. In the control group, the difference was statistically significant (P<0.01), and the SCE value of the inflammation group was significantly higher than that of the healthy group (P<0.01). The results suggest that genetic susceptibility may be involved in the pathogenesis of upper gastrointestinal cancer. Second, SCE detection may have some value in the follow-up of cancer family members.