论文部分内容阅读
用咖啡酸、阿魏酸对ＤＯＣＡ盐高血压大鼠内皮素１ 作用的进行了研究。结果表明：（１） 咖啡酸与阿魏酸能使得ＤＯＣＡ盐高血压大鼠的血压明显降低，与未加处置的阳性对照组相比，收缩压值的降低有明显差异；（２） 咖啡酸与阿魏酸能明显抑制ＤＯＣＡ盐高血压大鼠主动脉血管和心脏的组织增生；（３） 咖啡酸与阿魏酸能降低ＤＯＣＡ盐高血压大鼠血浆ＥＴ１ 浓度，与阳性对照组相比，除咖啡酸１００ｍｇ／ｋｇ 剂量组外，其余剂量组血浆ＥＴ１ 浓度的降低有显著性意义；（４） 三个剂量组的咖啡酸、阿魏酸可使得ＤＯＣＡ盐高血压大鼠的心脏、肾脏和主动脉血管ＥＴ１ｍ ＲＮＡ 的表达增加；（５） 三个剂量组的咖啡酸、阿魏酸均能抑制ＤＯＣＡ盐高血压大鼠心脏、肾脏和胸主动脉血管ｃｆｏｓ、热休克蛋白７０（ＨＳＰ７０） 基因的表达。本研究结果提示：咖啡酸与阿魏酸能通过对ＥＴ１ 的作用而产生对ＤＯＣＡ盐高血压大鼠降压、血管和心脏组织增生、原癌基因表达等生物效应。
With caffeic acid, ferulic acid on DOCA salt hypertensive rat endothelin 1 research. The results showed that: (1) Caffeic acid and ferulic acid could significantly reduce the blood pressure of DOCA-salt-induced hypertensive rats. Compared with the untreated positive control group, the systolic blood pressure decreased significantly. (2) Coffee Acid and ferulic acid can significantly inhibit DOCA salt hypertensive rats aortic vascular and cardiac tissue proliferation; (3) caffeic acid and ferulic acid can reduce DOCA salt hypertensive rats plasma ET 1 concentration, and positive Compared with the control group, in addition to caffeic acid 100mg / kg dose group, the remaining dose of plasma concentrations of ET 1 has a significant reduction; (4) three doses of caffeic acid, ferulic acid can make DOCA salt high Blood pressure rat heart, kidney and aortic vascular ET 1mRNA expression increased; (5) three doses of caffeic acid, ferulic acid can inhibit DOCA salt hypertensive rat heart, kidney and thoracic aorta Vascular c fos, heat shock protein 70 (HSP70) gene expression. The results of this study suggest that caffeic acid and ferulic acid can exert biological effects on the blood pressure, blood vessel and cardiac tissue proliferation and proto-oncogene expression in DOCAliquid hypertensive rats through the action of ET1.