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成分Bergamottine(5-geranyloxypsoralen)是从香柠檬(Citrus bergamia)非挥发精油中分离得到的一种化合物,文献报道Bergamottine具有明显的抗心律失常作用,本文对Bergamottine的抗心律失常作用进行分类研究,并阐明其作用机理。结果:①在变力和变时作用试验中,Bergamottine(5、10和20μg/ml)对豚鼠离体心房呈现负变时和变力作用,并有剂量依赖性。对自发性搏动右心房,Bergamottine的负变力作用超过其负变时作用。其对自发性搏动右心房的负变力和变时作用未能被阿托品(10~(-4)M)阻断,但能被Ach(10~(-4)M)阻断。表明Bergamottine
The ingredient Bergamottine (5-geranyloxypsoralen) is a compound isolated from the non-volatile essential oil of Citrus bergamia. It is reported that Bergamottine has obvious antiarrhythmic effect. In this paper, the anti-arrhythmic effects of Bergamottine were classified and studied. Explain its mechanism of action. RESULTS: 1Bergamottine (5, 10, and 20 μg/ml) exhibited negative and inotropic effects on the isolated atrial chambers of guinea pigs in a dose-dependent and time-dependent manner. In spontaneous right pulsation of the right atrium, the negative inotropic effect of Bergamottine exceeds its negative effect. Its negative inotropic and time-varying effects on the spontaneous right pulsation of the right atrium were not blocked by atropine (10-4 M) but could be blocked by Ach (10-4 M). Shows Bergamottine