论文部分内容阅读
本文报道经导管肝动脉内注入碘油丝裂霉素乳剂(LME)治疗肝癌的实验研究和临床应用。LME使丝裂霉素包围在油相之中,随碘油停留在肿瘤局部缓慢释放。注入后周围血药浓度测定和r闪烁扫描证明,药物在肿瘤局部有相当高的浓度而在周围血中浓度最低。可利用X线平片和CT观察随访肿瘤的变化。20例患者术后半年生存率达85%,3例已生存一年。
This article reports the experimental study and clinical application of transcatheter arterial injection of lipiodol mitomycin-emulsion (LME) to treat liver cancer. LME encloses mitomycin in the oil phase and slowly releases as the lipiodol stays in the tumor. Measurements of plasma concentrations and r-scattering scans after injection confirmed that the drug had a fairly high concentration at the tumor site and a minimal concentration in the peripheral blood. X-ray and CT can be used to observe the follow-up tumor changes. The half-year survival rate of 20 cases was 85%, and 3 cases had survived for one year.