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目的探讨胃肠间变性大细胞淋巴瘤(ALCL)的临床病理学特征、免疫组化表型特点。方法对3例确诊的胃肠间变性大细胞淋巴瘤患者的临床表现、组织学形态及免疫表型进行分析,并复习相关文献。结果胃肠间变性大细胞淋巴瘤的临床无特征性改变,组织学形态呈多形性,包括不等量的怪异核、马蹄核或肾形核,其中1例以肉瘤样特征为主。免疫组化:3例瘤细胞LCA、CD3、CD4、CD5、CD45RO和CD30均(+),2例ALK(+),B细胞相关抗原、CD15、肌源性、神经源性、上皮源性抗原均(-)。结论间变性大细胞淋巴瘤是罕见的胃肠道淋巴造血系统肿瘤,无明确临床特征,恶性度高,常误诊为癌或肉瘤,需要活检及病理确诊。
Objective To investigate the clinicopathological characteristics and immunohistochemical phenotype of large intestinal cell lymphoma (ALCL). Methods The clinical manifestations, histological features and immunophenotypes of 3 patients with diagnosed gastrointestinal anaplastic large cell lymphoma were analyzed and relevant literatures were reviewed. Results There was no clinical change in the characteristics of gastrointestinal interstitial large cell lymphoma. Histological morphology was pleomorphic, ranging from unequaled amounts of weird nucleus, horseshoe cortex or kidney nucleus. Among them, 1 was sarcomatoid. Immunohistochemistry: LCA, CD3, CD4, CD5, CD45RO and CD30 were all found in 3 cases of tumor cells, 2 cases of ALK (+), B cell related antigen, CD15, myogenic, neurogenic, all(-). Conclusion Anaplastic large cell lymphoma is a rare tumor of gastrointestinal lymphoid hematopoietic system. It has no definite clinical features, high malignancy, often misdiagnosed as carcinoma or sarcoma, and requires biopsy and pathological diagnosis.