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早在70年和74年,作者及其同事提出一种假说:认为细胞的恶性转化以及它的逆转(Reversion)是由恶性生长的表现基因(genes for expression,简称基因 E)和抑制基因(genes for suppression.简称基因 S)之间的平衡控制的。而这些基因位于不同的染色体上。在本研究里,作者用染色体的姬姆萨分带技术,进一步研究了金黄地鼠的转化细胞株,逆转株(revertant)和反逆转株(re-revertant)以及相应动物的肿瘤。作者发现转化的细胞株以及反逆转株在动物体内是致瘤的,而且都带有额外的5_7染色体。但逆转株细胞没有这种额外的5_7
As early as 70 and 74 years, the author and his colleagues proposed a hypothesis that the malignant transformation of cells and its reversion are gene expression for malignant growth genes (gene E) and gene repression (genes). For suppression. The abbreviation for the balance between gene S). And these genes are located on different chromosomes. In this study, the authors further studied the transformed cell lines, revertants and re-revertants of the golden hamster and the tumors of the corresponding animals using Giemsa chromosomal chromosomal banding techniques. The authors found that the transformed cell lines as well as the anti-retroviral strains were tumorigenic in animals and all had an additional 5 to 7 chromosomes. But reversing strain cells did not have this extra 5_7