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目的:观察在常规治疗基础上加用固本活血平喘方治疗慢性阻塞性肺疾病(COPD)老年患者的临床疗效。方法:根据随机数字表法将110例COPD肺肾气虚证老年患者分为对照组与观察组各55例,对照组接受常规治疗,观察组在常规治疗基础上加用固本活血平喘方,15天为1疗程,连续服用2疗程。观察2组血气分析指标、肺功能指标、气道重塑指标的变化,比较2组的临床疗效。结果:临床疗效显效率观察组为63.6%,对照组为40.0%,2组显效率比较,差异有统计学意义(P<0.05)。治疗后,2组血气分析指标、肺功能指标、气道重塑指标均较治疗前改善(P<0.05),观察组动脉血氧分压(Pa O2)、p H、血氧饱和度(Sa O2)、深吸气量(IC)、第1秒用力呼气量(FEV1)、FEV1与用力肺活量(FVC)的比值(FEV1/FVC)、FEV1占预计值百分比(FEV1%预计值)均高于对照组,二氧化碳分压(Pa CO2)、透明质酸(HA)、Ⅲ型前胶原(PCⅢ)值均低于对照组,差异均有统计学意义(P<0.05)。结论:在常规治疗基础上加用固本活血平喘方治疗COPD老年患者可以显著改善其肺功能,并且干预气道重塑,从而使患者获得更为显著的疗效。
Objective: To observe the clinical curative effect of treating chronic obstructive pulmonary disease (COPD) elderly patients by using Gubenhuoxue Pingchuan Decoction on the basis of routine treatment. Methods: According to the random number table method, 110 COPD patients with lung-kidney-qi deficiency syndrome were divided into control group and observation group with 55 cases in each group. The control group received routine treatment. The observation group was treated with Guben Huoxue Pingchuan Prescription, 15 days for a course of treatment, taking 2 courses. The blood gas analysis index, pulmonary function index and airway remodeling index were observed in two groups, and the clinical curative effect was compared between the two groups. Results: The effective rate of clinical curative effect was 63.6% in the observation group and 40.0% in the control group. There was significant difference between the two groups (P <0.05). After treatment, blood gas analysis index, lung function index and airway remodeling index were improved in both groups (P <0.05), PaO2, p H, Sa O2, FEV1, FEV1 / FVC and FEV1% predicted (FEV1% predicted) were both high In the control group, the values of PaCO 2, HA and PC Ⅲ were lower than those of the control group (P <0.05). CONCLUSION: Gubenhuoxue Pingchuan Recipe can significantly improve lung function in elderly patients with COPD on the basis of routine treatment, and interfere with airway remodeling so as to make the patients obtain more significant curative effect.