目的:探讨Leep术联合胶原蛋白海绵治疗宫颈重度糜烂的效果。方法:随机选取120例宫颈重度糜烂者采用Leep术联合胶原蛋白海绵为治疗组,116例单纯采用Leep术治疗为对照组,两组疗效进行比较。结果:治疗组Leep术后6周、8周治愈率分别为93.3%和97.5%,对照组分别为83.6%和90.5%,P<0.05。结论:Leep术联合胶原蛋白海绵治疗宫颈重度糜烂为较理想的方法。 Objective: To investigate the effect of Leep combined with collagen sponge in the treatment of severe cervical erosion. Methods: 120 cases of severe cervical erosion were selected by Leep combined with collagen sponge for the treatment group, 116 cases of simple treatment with Leep as the control group, the two groups were compared. Results: The cure rates of Leps after 6 weeks and 8 weeks in treatment group were 93.3% and 97.5% respectively, while those in control group were 83.6% and 90.5% respectively (P <0.05). Conclusion: Leep surgery combined with collagen sponge treatment of severe cervical erosion is the more ideal method.