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金霉素滴眼剂对防冶沙眼具有一定疗效,故在临床上已广泛应用。但金霉素的水溶液,不論加入緩冲剂或不加緩冲剂,在室溫中保存时,均不稳定,必須放在冰箱中,这对广泛应用有很大的限制性。上海市第六人民医院曾用金霉素游离硷制成油的混悬液供滴眼之用。近來出有应用金霉素油混悬液治疗中耳炎,并获得很好的疗效。金霉素油滴眼剂的稳定性问題是本研究的主要对象。为了扩大金霉素油剂所用植物油的来源,除按第六人民医院用药用
Chlortetracycline eye drops on the prevention and treatment of trachoma has a certain effect, it has been widely used in clinical practice. However, chlortetracycline aqueous solution, with or without buffering agent, is not stable when stored at room temperature and must be placed in the refrigerator, which is very restrictive for a wide range of applications. Sixth People’s Hospital of Shanghai had a chlortetracycline free base made of oil suspension for eye use. Recent application of chlortetracycline oil suspension in the treatment of otitis media, and get a good effect. The stability of chlortetracycline oil eye drops is the main target of this study. In order to expand the source of the oil used for chlortetracycline oil, except by the Sixth People’s Hospital medicinal