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本研究对32例慢性活动性肝炎患者肝穿活检标本,经透射电镜超薄切片样品常规制作后,应用H—600电子显微镜,着重对淋巴细胞与肝细胞亚微病理损伤之间的关系和纤维组织增生病变进行观察,试从亚微病理水平探讨细胞免疫或致敏淋巴细胞在慢活肝发病机理中的意义。慢活肝时,肝组织中肝细胞损伤范围广泛,淋巴细胞数目增多,变性的肝细胞周围常有淋巴细胞浸润,这些功能活跃的致敏淋巴细胞细胞器发达,且多有伪足样细胞突起伸向邻近肝细胞,与肝细胞质膜发生多点接触或相互融合,有的淋巴细胞甚至随肝细胞膜陷入肝细胞中或穿过肝细胞膜进入肝细胞内[图1]。受
In this study, 32 patients with chronic active hepatitis liver biopsy specimens were routinely fabricated with transmission electron microscopy ultrathin section samples. Using the H-600 electron microscope, the relationship between fibrosis and the subtle lesions of lymphocytes and hepatocytes was emphasized. To observe the hyperplastic lesions and explore the significance of cellular immunity or sensitized lymphocytes in the pathogenesis of chronic liver disease from the submicroscopic pathological level. When liver is slowly mobilized, the hepatic cells in the hepatic tissue are extensively damaged, the number of lymphocytes increases, lymphocytes infiltrates around the denatured hepatocytes, and these functionally active sensitized lymphocytes have well-developed organelles and many pseudopod-like cells protrude. To neighboring hepatocytes, multiple contact or fusion occurs with the plasma membrane of hepatocytes, and some of the lymphocytes even fall into hepatocytes through the hepatocyte membrane or enter the hepatocytes through the hepatocyte membrane [Fig. 1]. Accept