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目的：探讨转移相关基因CD44V6蛋白产物在人鼻咽癌中的表达特点及其与颈淋巴结转移和其它生物学行为的关系。方法：采用免疫组化S－P法对73例低分化鼻咽癌和12例慢性鼻咽炎上皮进行蛋白产物的检测。结果：CD44V6蛋白的阳性表达率在慢性鼻咽炎组中为5／12（41．7%），在鼻咽癌组中58/73（79．5%），两组比率有明显差异性，颈淋巴结转移组CD44V6蛋白阳性率明显高于无淋巴结转移组。结论：5例（41．7％）慢性鼻咽炎上皮蛋白表达均在基底层。CD44V6蛋白表达升高可能在鼻咽癌的发生过程中起一定作用。并与颈淋巴结转移有关，但与周围组织浸润无关。
Objective: To investigate the expression of metastasis-associated gene CD44V6 protein in human nasopharyngeal carcinoma and its relationship with cervical lymph node metastasis and other biological behaviors. Methods: The protein products of 73 cases of poorly differentiated nasopharyngeal carcinoma and 12 cases of chronic nasopharyngitis epithelium were detected by immunohistochemical S-P method. Results: The positive rate of CD44V6 protein was 5/12 (41.7%) in chronic nasopharyngitis group and 58/73 (79.5%) in nasopharyngeal carcinoma group. There was significant difference between the two groups The positive rate of CD44V6 protein in lymph node metastasis group was significantly higher than that in non-lymph node metastasis group. Conclusion: The expression of epithelial protein in 5 cases (41.7%) of chronic nasopharyngitis is in basal layer. CD44V6 protein expression may play a role in the occurrence of nasopharyngeal carcinoma. And cervical lymph node metastasis, but not with the surrounding tissue infiltration.