近年来,随着对细胞毒反应研究的不断深入,人们相继发现多种刺激物均可在体外激活正常或带瘤宿主外周血单个核细胞或脾细胞,并使其分化成为具有广谱杀瘤效应的非特异性细胞毒细胞。我们采用国产615近交系小鼠脾细胞进行体外培养,在缺乏特异性抗原刺激又无外加淋巴因子的情况下,也诱导出具有广谱杀伤效应的细胞毒淋 In recent years, with the deepening of the research on cytotoxicity, one after another found that a variety of stimuli can be activated in vitro normal or tumor-bearing host peripheral blood mononuclear cells or spleen cells, and make it into a broad-spectrum kill tumor Effect of non-specific cytotoxic cells. We use domestic 615 inbred mouse spleen cells cultured in vitro, in the absence of specific antigen-stimulated and without additional lymphokine, but also induced a broad-spectrum cytotoxic effect of cytotoxicity