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目的探讨不同程度羊水胎粪污染新生儿血清神经元特异性烯醇化酶(NSE)水平。方法选择2010年6月至2011年12月本院新生儿科收治的生后Apgar评分正常、单纯因羊水胎粪污染入院的足月新生儿为观察组,并根据羊水胎粪污染程度分为羊水Ⅰ～Ⅱ度胎粪污染组和羊水Ⅲ度胎粪污染组,同期选择本院产科分娩无羊水胎粪污染的足月健康新生儿为对照组,对比分析3组新生儿的NSE水平。结果羊水Ⅲ度胎粪污染组血清NSE水平(39.9±10.4)μg/L,明显高于羊水Ⅰ～Ⅱ度胎粪污染组(13.5±3.2)μg/L及对照组(8.6±3.6)μg/L,差异有统计学意义(P<0.05),羊水Ⅰ～Ⅱ度污染组与对照组比较差异无统计学意义(P>0.05)。结论羊水Ⅲ度胎粪污染新生儿即使Apgar评分正常,仍可能存在缺氧后脑损伤,需要密切观察。
Objective To investigate the levels of serum neuron-specific enolase (NSE) in neonates with meconium-stained amniotic fluid. Methods From June 2010 to December 2011, the Apgar score of postnatal neonates in our hospital was normal, and the full-term newborns admitted to hospital due to meconium-stained amniotic fluid meconium were divided into observation group and amniotic fluid Ⅰ ~ Ⅱ degree meconium-stained group and amniotic fluid third-degree meconium-stained group. The full-term healthy neonates without meconium-stained amniotic fluid in our hospital were selected as the control group in the same period. The levels of NSE were compared between the three groups. Results The level of serum NSE in amniotic fluid Ⅲ degree meconium-stained group (39.9 ± 10.4) μg / L was significantly higher than that in amniotic fluid Ⅰ- Ⅱ degree meconium-stained group (13.5 ± 3.2) μg / L and control group (8.6 ± 3.6) μg / L, the difference was statistically significant (P <0.05), Amniotic fluid Ⅰ ~ Ⅱ degree of pollution group compared with the control group, no significant difference (P> 0.05). Conclusion Neonates with third degree meconium-stained amniotic fluid may still have hypoxic-ischemic brain injury even though Apgar score is normal, which needs close observation.