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目的观察曲美他嗪对不稳定型心绞痛患者冠状动脉介入术(PCI)过程中血清白细胞介素6(IL-6)和C反应蛋白(CRP)浓度的影响。方法75例拟行PCI治疗的不稳定型心绞痛患者,随机分为曲美他嗪组和对照组,分别于PCI前、术后即刻(0h)、2h和6h采取冠状静脉窦血样测定血清IL-6的浓度;另于术前、术后6、24和48h采取肘静脉血样,测定血清CRP的浓度。血清IL-6和CRP的浓度均以ELISA双抗体夹心法进行测定。结果2组患者临床特征及靶病变情况差异无统计学意义。对照组IL-6浓度在术后即刻开始高于曲美他嗪组,术后2h和6h差异进一步增大(P<0.05~0.01)。对照组的CRP浓度在术后6、24和48h都明显高于曲美他嗪组(P<0.05~0.01)。结论曲美他嗪能抑制不稳定型心绞痛患者PCI过程中血清IL-6和CRP浓度的升高。
Objective To investigate the effect of trimetazidine on serum interleukin 6 (IL-6) and C-reactive protein (CRP) during coronary artery surgery (PCI) in patients with unstable angina pectoris. Methods Seventy-five patients with unstable angina pectoris undergoing PCI were randomly divided into trimetazidine group and control group. Coronary venous blood samples were taken before and immediately after PCI (0h, 2h and 6h) respectively to measure serum IL- 6 concentrations; the other before surgery, 6,24 and 48h after surgery to take cubital vein blood samples were measured serum CRP concentrations. Serum IL-6 and CRP concentrations were measured by ELISA double antibody sandwich method. Results There was no significant difference in clinical features and target lesions between the two groups. The concentration of IL-6 in the control group began to be higher than that of the trimetazidine group immediately after operation, and the difference was further increased at 2h and 6h after operation (P <0.05-0.01). The concentration of CRP in the control group was significantly higher than that of the trimetazidine group at 6, 24 and 48 hours after operation (P <0.05 ~ 0.01). Conclusion Trimetazidine can inhibit the increase of serum IL-6 and CRP levels in patients with unstable angina pectoris during PCI.