论文部分内容阅读
Aim:To investigate the effect of epidermal growth factor(EGF)on the sperm content and motility of the varicocelizedrats.Methods:Forty-eight male Wistar rats were randomly divided into five groups.Experimental varicocele wasinduced by partial ligation of the left renal vein in the varicocele,the varicocele repair,the varicocele with EGF and thevaricocele repair with EGF groups,whereas the control group only received a sham induction of varicocele.Surgicalrepair of varicocele was performed 4 months later in the varicocele repair and varicocele repair with EGF groups.EGF administration was performed daily by s.c.injection in the varicocele with EGF and varicocele repair with EGFgroups at the dose of 10μg/(kg.day)from the next day of the second surgery.One month later,all animals werekilled and bilateral cauda epididymal sperm counts and motility were evaluated.Results:The mean sperm count andpercentage of motile spermatozoa were significantly higher bilaterally in the varicocele with EGF group than in thevaricocele group(P<0.05).They were also significantly higher bilaterally in the varicocele repair with EGF groupthan in the varicocele repair and the varicocele with EGF groups(P<0.05).Conclusion:EGF can improve bilateralepididymal sperm content and motility of the rat with surgically induced varicocele.The administration of EGF incombination with surgical repair is more effective than surgical repair or EGF administration alone.EGF might beuseful for the treatment of infertility induced by varicocele.(Asian JAndrol 2006 Nov;8:713-717)
Aim: To investigate the effect of epidermal growth factor (EGF) on the sperm content and motility of the varicocelized devices. Forty-eight male Wistar rats were differentiated into five groups. Experimental varicocele was induced by partial ligation of the left renal vein in the varicocele, the varicocele repair, the varicocele with EGF and the varicocele repair with EGF groups, the control group only received a sham induction of varicocele. Surgical rempair of varicocele was performed 4 months later in the varicocele repair and varicocele repair with EGF groups. EGF administration was performed daily by scinjection in the varicocele with EGF and varicocele repair with EGF groups at the dose of 10 μg / (kg.day) from the next day of the second surgery. One month later, all animals werekilled and bilateral cauda epididymal sperm counts and motility were evaluated. Results: The mean sperm count and percentage of motile spermatozoa were significantly higher bilaterally in the varicocele with EGF They were also significantly higher bilaterally in the varicocele repair with EGF groupthan in the varicocele repair and the varicocele with EGF groups (P <0.05) .Conclusion: EGF can improve bilateralepididymal sperm content and motility of the rat with surgically induced varicocele. The administration of EGF incombination with surgical repair is more effective than surgical repair or EGF administration alone. EGF was probably for use for the treatment of infertility induced by varicocele. (Asian JAndrol 2006 Nov; 8: 713-717 )