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目的观察甘草酸二铵治疗急性脑梗死的临床疗效。方法急性脑梗死患者120例,随机分为对照组和试验组,每组60例,2组患者均予以抗血小板聚集、他汀类药物、脑保护、改善循环、控制血压等常规神经内科治疗,试验组加用甘草酸二铵治疗,于入院第1,14,21天分别采用美国国立卫生院神经功能缺损评分(NIHSS)评价神经功能缺损程度,并测定超敏C反应蛋白(hs-CRP)的水平,评价疗效。结果试验组NIHSS评分、hs-CRP水平在第14,21天明显低于对照组,差异有统计学意义。试验组临床有效率(76.7%)显著高于对照组(60.0%),差异有统计学意义。结论甘草酸二铵能减轻脑梗死患者神经功能缺失症状,提高临床有效率,其机制可能与减轻炎症反应有关。
Objective To observe the clinical effect of diammonium glycyrrhizinate in the treatment of acute cerebral infarction. Methods A total of 120 patients with acute cerebral infarction were randomly divided into control group and experimental group, 60 cases in each group. The patients in both groups were given antiplatelet aggregation, statins, cerebral protection, circulation improvement and blood pressure control, Groups were given diammonium glycyrrhizinate. On the 1st, 14th and 21st day of admission, the neurological deficit score (NIHSS) of the National Institutes of Health was used to evaluate the degree of neurological deficit, and the levels of hs-CRP Level, evaluate the efficacy. Results The NIHSS scores and hs-CRP levels in the experimental group were significantly lower than those in the control group on the 14th and 21st days, with significant difference. The clinical effective rate (76.7%) in the experimental group was significantly higher than that in the control group (60.0%), the difference was statistically significant. Conclusion Diammonium glycyrrhizinate can alleviate the symptoms of neurological deficits in patients with cerebral infarction and improve the clinical efficiency, the mechanism may be related to the reduction of inflammatory reaction.