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目的探讨去甲肾上腺素治疗小儿严重脓毒症的临床治疗效果。方法 100例小儿严重脓毒症患儿,随机分为对照组和实验组,每组50例。对照组采用常规方法治疗,实验组在对照组基础上加用去甲肾上腺素治疗,比较两组的临床效果及不良反应。结果实验组治疗后住院死亡率为12%,显著低于对照组的30%(P<0.05);实验组患儿急性生理和慢性健康评分系统Ⅱ(APACHE Ⅱ)评分及住儿科重症监护室(PICU)时间显著低于对照组(P<0.05);实验组不良反应发生率为8%,显著低于对照组的22%(P<0.05)。结论去甲肾上腺素治疗小儿严重脓毒症的临床治疗效果理想,患儿死亡率相对降低,住PICU时间较短,值得推广应用。
Objective To investigate the clinical effect of norepinephrine in the treatment of severe sepsis in children. Methods 100 cases of children with severe sepsis were randomly divided into control group and experimental group, 50 cases in each group. The control group was treated by conventional method. The experimental group was treated with norepinephrine on the basis of the control group. The clinical effects and adverse reactions of the two groups were compared. Results The in-hospital mortality was 12% in the experimental group after treatment, which was significantly lower than that in the control group (P <0.05). The acute physiology and chronic health score system Ⅱ (APACHE Ⅱ) and the pediatric intensive care unit PICU) was significantly lower than the control group (P <0.05). The incidence of adverse reactions in the experimental group was 8%, which was significantly lower than that of the control group (22%, P <0.05). Conclusion The clinical effect of norepinephrine in the treatment of severe sepsis in children is satisfactory. The mortality rate in children is relatively lower, and the PICU residence time is shorter, which is worth popularizing and applying.