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研究了ＳＯ_２在体内的衍生物一亚硫酸氢钠和亚硫酸钠对中国仓鼠肺纤维细胞（ＣＨＬ）细胞染色体畸变（ＣＡ）的诱发作用研究结果表明，ＳＯ_２的衍生物不论是否有Ｓ_９混合物的存在情况下，均可诱发ＣＨＬ细胞的ＣＡ频率显著增高，且呈明确的剂量一效应关系．这说明ＳＯ_２不需要体内代谢转化的直接的细胞染色体断裂剂和基因毒性因子研究亦发现，ＳＯ_２产低浓度下主要诱发染色单体型畸变，在高浓度下既可引起染色单体型畸变，又可引起染色体型畸变研究还发现，ＳＯ_２衍生物处理细胞时间愈长，引起细胞遗传损伤所需的最低浓度就越低．提示：长期接触环境低浓度ＳＯ_２污染，有引起接触人群体内细胞遗传物质损伤的潜在危险。
Studies on the induction of chromosomal aberrations (CA) in Chinese hamster lung fibroblasts (CHL) cells by SO2-sodium bisulfite and sodium sulfite in vivo showed that the derivatives of SO2, whether or not there is S9 mixture, , All can induce the CA frequency of CHL cells significantly increased, and a clear dose-response relationship. This shows that SO 2 does not require in vivo metabolism of direct chromosomal cleavage agents and genotoxicity studies also found that SO 2 at low concentrations mainly induced chromatid haplotype distortion in high concentrations can cause chromatid haplotype distortion, and Studies that cause chromosome aberrations also found that the longer the SO2 derivatives are treated, the lower the minimum concentration required to cause genetic damage to the cells. Hint: Long-term exposure to environmental low concentrations of SO 2 pollution may cause potential risks of damage to cytogenetic material in contact with the population.