In this paper, adaptive neural tracking control is proposed based on radial basis function neural networks (RBFNNs) for a class of multi-input multi-output (MIMO) nonlinear systems with completely unknown control directions, unknown dynamic disturbances, unmodeled dynamics, and uncertainties with time-varying delay. Using the Nussbaum function properties, the unknown control directions are dealt with. By constructing appropriate Lyapunov-Krasovskii functionals, the unknown upper bound functions of the time-varying delay uncertainties are compensated. The proposed control scheme does not need to calculate the integral of the delayed state functions. Using Young s inequality and RBFNNs, the assumption of unmodeled dynamics is relaxed. By theoretical analysis, the closed-loop control system is proved to be semi-globally uniformly ultimately bounded. In this paper, adaptive neural tracking control is proposed based on radial basis function neural networks (RBFNNs) for a class of multi-input multi-output (MIMO) nonlinear systems with completely unknown control directions, unknown dynamic disturbances, unmodeled dynamics, and uncertainties Using the Nussbaum function properties, the unknown control directions are dealt with. By constructing appropriate Lyapunov-Krasovskii functionals, the unknown upper bound functions of the time-varying delay uncertainties are compensated. The proposed control scheme does not need To calculate the integral of the delayed state functions. Using Youngs inequality and RBFNNs, the assumption of unmodeled dynamics is relaxed. By theoretical analysis, the closed-loop control system is proved to be semi-centrally located ultimately bounded.