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蛋白S(protein S,PS)是一种维生素K依赖性天然抗凝剂,约60％与C4结合蛋白结合为无活性结合型PS(C4bPS),余则为游离型PS(fPS),具有生物活性。1％～7％的深静脉血栓形成患者显示PS缺乏,但普通人群中遗传性PS缺乏的流行病学情况尚不清楚。 方法 3788例健康志愿者,年龄17～68岁;其中男2106例、女1682例[1467例(87％)绝经期前,453例(31％)口服避孕药,29例(15％)使用激素替代疗法(HRT)],无心、肾、肝脏病史;不排除静脉栓塞病史者,但不包括使用
Protein S (PS) is a natural vitamin K-dependent anticoagulant. About 60% binds to C4-binding protein as inactive bound PS (C4bPS), whereas the rest is free-form PS (fPS) active. 1% to 7% of patients with deep venous thrombosis show PS deficiency, but the prevalence of inherited PS deficiency in the general population is not known. METHODS: A total of 3788 healthy volunteers, aged 17-68 years old, including 2106 males and 1682 females [1467 (87%]), 453 (31%) oral contraceptives and 29 (15% Replacement Therapy (HRT)], no heart, kidney, liver history; does not rule out history of venous embolism, but does not include the use of