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溃疡性结肠炎(UC)近年来患病率呈上升趋势,其发生机制尚不清楚.IL-6本要是由T、B细胞和单核-巨噬细胞分泌的细胞因子,在机体的炎症反应和免疫调节过程中发挥重要作用.作为重要炎症和免疫介导因子的IL-6可能涉及UC的病理过程,为此,本文采用双抗体夹心ELISA法测定了33例UC患者血清IL-6水平,并探讨其在UC发生发展中的作用和临床意义.1 材料与方法1.1 研究对象 活动期UC患者33例,男17例,女16例,年龄25岁～67岁;病程2月～15年不等.全部病例都符合1993年太原会议制定的UC诊断标准.并根据该标准将33例UC患者分为轻(7例)、中(20例)、重度(6例)3级.上述病例经内科系统治疗病情缓解者(缓解期)15例.正常对照组40例,均来自健康体检者,除外感染、风湿病和肿瘤疾病.
In recent years, the prevalence of ulcerative colitis (UC) is on the rise, the mechanism of which is not yet clear.IL-6 is a cytokine secreted by T, B cells and monocytes - macrophages in the body’s inflammatory response And immune regulation plays an important role in the pathogenesis of UC as an important inflammatory and immune mediators of IL-6 may be involved in this study, the sandwich ELISA was used to determine the serum IL-6 levels in 33 patients with UC, And explore its role in the occurrence and development of UC and its clinical significance.Materials and Methods 1.1 Subjects: 33 active UC patients, 17 males and 16 females, aged 25 to 67 years; duration of 2 months to 15 years , Etc. All the cases were in line with the diagnostic criteria of UC established by Taiyuan Conference in 1993. According to the standard, 33 UC patients were classified as mild (7 cases), moderate (20 cases) and severe (6 cases) Internal medicine system for the treatment of remission (remission) in 15. Normal control group of 40 patients, all from the health examination, except for infection, rheumatism and cancer disease.