慢性移植肾功能不全(CRAD)是一种进行性肾脏功能障碍,是晚期移植物恶化和衰竭的首要原因。在其发展的不同阶段需随时调整免疫抑制方案,提供最适宜的治疗。新的治疗方案是在亚临床急性排斥反应风险最大的阶段应用CNI为主的治疗方案,然后转换成不含CNI的治疗方案,以避免肾毒性的长期后果。 Chronic graft renal insufficiency (CRAD) is a progressive renal dysfunction that is the leading cause of advanced graft deterioration and failure. At different stages of its development, immunosuppressive regimens need to be adjusted at any time to provide the most appropriate treatment. The new regimen is to apply a CNI-based regimen at the highest risk of subclinical acute rejection and then switch to a CNI-free regimen to avoid the long-term consequences of nephrotoxicity.